Effects of tetrahydrouridine on pharmacokinetics and pharmacodynamics of oral decitabine

The deoxycytidine analog decitabine (DAC) can deplete DNA methyl-transferase 1 (DNMT1) and thereby modify cellular epigenetics, gene expression, and differentiation. However, a barrier to efficacious and accessible DNMT1-targeted therapy is cytidine deaminase, an enzyme highly expressed in the intes...

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Dettagli Bibliografici
Autori principali: Lavelle, Donald, Vaitkus, Kestis, Ling, Yonghua, Ruiz, Maria A., Mahfouz, Reda, Ng, Kwok Peng, Negrotto, Soledad, Smith, Nicola, Terse, Pramod, Engelke, Kory J., Covey, Joseph, Chan, Kenneth K., DeSimone, Joseph, Saunthararajah, Yogen
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2012
Soggetti:
Red Cells, Iron, and Erythropoiesis
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3277356/
https://ncbi.nlm.nih.gov/pubmed/22160381
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-08-371690
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