Durable donor engraftment after radioimmunotherapy using α-emitter astatine-211–labeled anti-CD45 antibody for conditioning in allogeneic hematopoietic cell transplantation

To reduce toxicity associated with external γ-beam radiation, we investigated radioimmunotherapy with an anti-CD45 mAb labeled with the α-emitter, astatine-211 ((211)At), as a conditioning regimen in dog leukocyte antigen-identical hematopoietic cell transplantation (HCT). Dose-finding studies in 6...

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Main Authors: Chen, Yun, Kornblit, Brian, Hamlin, Donald K., Sale, George E., Santos, Erlinda B., Wilbur, D. Scott, Storer, Barry E., Storb, Rainer, Sandmaier, Brenda M.
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2012
Fag:
Clinical Trials and Observations
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3277350/
https://ncbi.nlm.nih.gov/pubmed/22134165
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-09-380436
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