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Rad51 Promoter-Targeted Gene Therapy Is Effective for In Vivo Visualization and Treatment of Cancer

Rad51 protein is overexpressed in a wide range of human cancers. Our previous in vitro studies demonstrated that a construct comprised Rad51 promoter driving expression of the diphtheria toxin A gene (pRad51-diphtheria toxin A (DTA)) destroys a variety of human cancer cell lines, with minimal to no...

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Bibliografiske detaljer
Main Authors: Hine, Christopher M, Seluanov, Andrei, Gorbunova, Vera
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2012
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3277325/
https://ncbi.nlm.nih.gov/pubmed/22008909
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2011.215
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