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Use of the Rad51 promoter for targeted anti-cancer therapy

Rad51 protein, involved in homologous recombination, is overexpressed in a variety of tumors, and its expression is correlated with a poor prognosis. Here we propose to exploit the overexpression of Rad51 in cancer cells to design a Rad51 promoter-based anticancer therapy. On average, Rad51 mRNA and...

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Bibliografiske detaljer
Main Authors: Hine, Christopher M., Seluanov, Andrei, Gorbunova, Vera
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2008
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2634908/
https://ncbi.nlm.nih.gov/pubmed/19106292
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0807990106
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