Atelocollagen-mediated Systemic Delivery Prevents Immunostimulatory Adverse Effects of siRNA in Mammals

Short interfering RNA (siRNA) is a potent activator of the mammalian innate immune system. When considering possible clinical applications of siRNA for humans, the adverse immunostimulatory effects must also be taken into account. Here, we show that atelocollagen-mediated systemic delivery of siRNA...

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Bibliographische Detailangaben
Hauptverfasser: Inaba, Shinichiro, Nagahara, Shunji, Makita, Naoki, Tarumi, Yuzo, Ishimoto, Takuji, Matsuo, Seiichi, Kadomatsu, Kenji, Takei, Yoshifumi
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2012
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3277238/
https://ncbi.nlm.nih.gov/pubmed/22031237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2011.221
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