Atelocollagen-mediated Systemic Delivery Prevents Immunostimulatory Adverse Effects of siRNA in Mammals

Short interfering RNA (siRNA) is a potent activator of the mammalian innate immune system. When considering possible clinical applications of siRNA for humans, the adverse immunostimulatory effects must also be taken into account. Here, we show that atelocollagen-mediated systemic delivery of siRNA...

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Detalhes bibliográficos
Main Authors: Inaba, Shinichiro, Nagahara, Shunji, Makita, Naoki, Tarumi, Yuzo, Ishimoto, Takuji, Matsuo, Seiichi, Kadomatsu, Kenji, Takei, Yoshifumi
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3277238/
https://ncbi.nlm.nih.gov/pubmed/22031237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2011.221
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