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Crystal structure of a Tankyrase-Axin complex and its implications for Axin turnover and Tankyrase substrate recruitment

Axin is a tumor suppressor and a key negative regulator of the Wnt/β-catenin signaling pathway. Axin turnover is controlled by its poly-ADP-ribosylation catalyzed by tankyrase (TNKS), which requires the direct interaction of Axin with TNKS. This interaction is thus an attractive drug target for trea...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Morrone, Seamus, Cheng, Zhihong, Moon, Randall T., Cong, Feng, Xu, Wenqing
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: National Academy of Sciences 2012
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3277157/
https://ncbi.nlm.nih.gov/pubmed/22307604
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1116618109
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