Nalaganje...
Crystal structures of the extracellular domain of LRP6 and its complex with DKK1
LRP5 and LRP6 are Wnt co-receptors essential for Wnt/β-catenin signaling. DKK1 inhibits Wnt signaling by interacting with the extracellular domain of LRP5/6, and is a drug target for multiple diseases. Here we present the crystal structures of the first and second halves of LRP6’s four propeller–EGF...
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| Main Authors: | , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2011
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3249237/ https://ncbi.nlm.nih.gov/pubmed/21984209 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2139 |
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