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Automated selection of stabilizing mutations in designed and natural proteins
The ability to engineer novel protein folds, conformations, and enzymatic activities offers enormous potential for the development of new protein therapeutics and biocatalysts. However, many de novo and redesigned proteins exhibit poor hydrophobic packing in their predicted structures, leading to in...
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
National Academy of Sciences
2012
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3277135/ https://ncbi.nlm.nih.gov/pubmed/22307603 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1115172109 |
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