DNA Methylation Signatures in Development and Aging of the Human Prefrontal Cortex

The human prefrontal cortex (PFC), a mastermind of the brain, is one of the last brain regions to mature. To investigate the role of epigenetics in the development of PFC, we examined DNA methylation in ∼14,500 genes at ∼27,000 CpG loci focused on 5′ promoter regions in 108 subjects range in age fro...

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Bibliografiske detaljer
Main Authors: Numata, Shusuke, Ye, Tianzhang, Hyde, Thomas M., Guitart-Navarro, Xavier, Tao, Ran, Wininger, Michael, Colantuoni, Carlo, Weinberger, Daniel R., Kleinman, Joel E., Lipska, Barbara K.
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2012
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3276664/
https://ncbi.nlm.nih.gov/pubmed/22305529
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajhg.2011.12.020
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