Transcript-Specific Associations of SLC12A5 (KCC2) in Human Prefrontal Cortex with Development, Schizophrenia, and Affective Disorders

The neuron-specific K(+)-Cl(−) cotransporter SLC12A5, also known as KCC2, helps mediate the electrophysiological effects of GABA. The pattern of KCC2 expression during early brain development suggests that its upregulation drives the postsynaptic switch of GABA from excitation to inhibition. We prev...

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Autors principals: Tao, Ran, Li, Chao, Newburn, Erin N., Ye, Tianzhang, Lipska, Barbara K., Herman, Mary M., Weinberger, Daniel R., Kleinman, Joel E., Hyde, Thomas M.
Format: Artigo
Idioma:Inglês
Publicat: Society for Neuroscience 2012
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3752043/
https://ncbi.nlm.nih.gov/pubmed/22496567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.4626-11.2012
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