Low-Pass Genome-Wide Sequencing and Variant Inference Using Identity-by-Descent in an Isolated Human Population

Whole-genome sequencing in an isolated population with few founders directly ascertains variants from the population bottleneck that may be rare elsewhere. In such populations, shared haplotypes allow imputation of variants in unsequenced samples without resorting to complex statistical methods as i...

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Bibliografische gegevens
Hoofdauteurs: Gusev, A., Shah, M. J., Kenny, E. E., Ramachandran, A., Lowe, J. K., Salit, J., Lee, C. C., Levandowsky, E. C., Weaver, T. N., Doan, Q. C., Peckham, H. E., McLaughlin, S. F., Lyons, M. R., Sheth, V. N., Stoffel, M., De La Vega, F. M., Friedman, J. M., Breslow, J. L., Pe’er, I.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Genetics Society of America 2012
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Investigations
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3276614/
https://ncbi.nlm.nih.gov/pubmed/22135348
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.111.134874
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