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Subcellular Location of PKA Controls Striatal Plasticity: Stochastic Simulations in Spiny Dendrites

Dopamine release in the striatum has been implicated in various forms of reward dependent learning. Dopamine leads to production of cAMP and activation of protein kinase A (PKA), which are involved in striatal synaptic plasticity and learning. PKA and its protein targets are not diffusely located th...

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Autores principales: Oliveira, Rodrigo F., Kim, MyungSook, Blackwell, Kim T.
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2012
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3276550/
https://ncbi.nlm.nih.gov/pubmed/22346744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1002383
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