The role of type 4 phosphodiesterases in generating microdomains of cAMP: large scale stochastic simulations.

Cyclic AMP (cAMP) and its main effector Protein Kinase A (PKA) are critical for several aspects of neuronal function including synaptic plasticity. Specificity of synaptic plasticity requires that cAMP activates PKA in a highly localized manner despite the speed with which cAMP diffuses. Two mechani...

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Main Authors: Rodrigo F Oliveira, Anna Terrin, Giulietta Di Benedetto, Robert C Cannon, Wonryull Koh, MyungSook Kim, Manuela Zaccolo, Kim T Blackwell
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science (PLoS) 2010-07-01
Serija:PLoS ONE
Online dostop:http://europepmc.org/articles/PMC2908681?pdf=render
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