The Role of Type 4 Phosphodiesterases in Generating Microdomains of cAMP: Large Scale Stochastic Simulations

Cyclic AMP (cAMP) and its main effector Protein Kinase A (PKA) are critical for several aspects of neuronal function including synaptic plasticity. Specificity of synaptic plasticity requires that cAMP activates PKA in a highly localized manner despite the speed with which cAMP diffuses. Two mechani...

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Detalhes bibliográficos
Main Authors: Oliveira, Rodrigo F., Terrin, Anna, Di Benedetto, Giulietta, Cannon, Robert C., Koh, Wonryull, Kim, MyungSook, Zaccolo, Manuela, Blackwell, Kim T.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2908681/
https://ncbi.nlm.nih.gov/pubmed/20661441
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0011725
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