A Genomewide Screen for Suppressors of Alu-Mediated Rearrangements Reveals a Role for PIF1

Alu-mediated rearrangement of tumor suppressor genes occurs frequently during carcinogenesis. In breast cancer, this mechanism contributes to loss of the wild-type BRCA1 allele in inherited disease and to loss of heterozygosity in sporadic cancer. To identify genes required for suppression of Alu-me...

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Main Authors: Chisholm, Karen M., Aubert, Sarah D., Freese, Krister P., Zakian, Virginia A., King, Mary-Claire, Welcsh, Piri L.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2012
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3276492/
https://ncbi.nlm.nih.gov/pubmed/22347400
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0030748
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