Adenomatous polyposis coli heterozygous knockout mice display hypoactivity and age-dependent working memory deficits

A tumor suppressor gene, Adenomatous polyposis coli (Apc), is expressed in the nervous system from embryonic to adulthood stages, and transmits the Wnt signaling pathway in which schizophrenia susceptibility genes, including T-cell factor 4 (TCF4) and calcineurin (CN), are involved. However, the fun...

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Detalhes bibliográficos
Main Authors: Koshimizu, Hisatsugu, Fukui, Yasuyuki, Takao, Keizo, Ohira, Koji, Tanda, Koichi, Nakanishi, Kazuo, Toyama, Keiko, Oshima, Masanobu, Taketo, Makoto Mark, Miyakawa, Tsuyoshi
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2011
Assuntos:
Neuroscience
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3276361/
https://ncbi.nlm.nih.gov/pubmed/22347851
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnbeh.2011.00085
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