Targeted Delivery of Cisplatin to Lung Cancer Using ScFvEGFR-Heparin-Cisplatin Nanoparticles

The clinical application of cis-diamminedichloroplatinum(II) (DDP, cisplatin) for cancer therapy is limited by its non-specific biodistribution and severe side effects. Here, we have developed EGFR-targeted heparin-DDP (EHDDP) nanoparticles for tumor targeted delivery of DDP. This nanoparticle deliv...

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Bibliografiske detaljer
Main Authors: Peng, Xiang-Hong, Wang, Yiqing, Huang, Donghai, Wang, Yuxiang, Shin, Hyung Juc., Chen, Zhengjia, Spewak, Micheal B, Mao, Hui, Wang, Xu, Wang, Ying, Chen, Zhuo (Georgia), Nie, Shuming, Shin, Dong M.
Format: Artigo
Sprog:Inglês
Udgivet: 2011
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3275811/
https://ncbi.nlm.nih.gov/pubmed/22032622
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/nn202410f
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