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Binding Modes of μ-Conotoxin to the Bacterial Sodium Channel (Na(V)Ab)
Polypeptide toxins isolated from the venom of cone snails, known as μ-conotoxins, block voltage-gated sodium channels by physically occluding the ion-conducting pathway. Using molecular dynamics, we show that one subtype of μ-conotoxins, PIIIA, effectively blocks the bacterial voltage-gated sodium c...
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| Main Authors: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
The Biophysical Society
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3274799/ https://ncbi.nlm.nih.gov/pubmed/22325270 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2011.12.041 |
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