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Mapping general anesthetic binding site(s) in human α1β3 γ-aminobutyric acid type A receptors with [(3)H]TDBzl-etomidate, a photoreactive etomidate analog()

The γ-aminobutyric acid type-A receptor (GABA(A)R) is a target for general anesthetics of diverse chemical structures, which act as positive allosteric modulators at clinical doses. Previously, in a heterogeneous mixture of GABA(A)Rs purified from bovine brain, [(3)H]azietomidate photolabeling of αM...

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Bibliografske podrobnosti
Main Authors: Chiara, David C., Dostalova, Zuzana, Jayakar, Selwyn S., Zhou, Xiaojuan, Miller, Keith W., Cohen, Jonathan B.
Format: Artigo
Jezik:Inglês
Izdano: 2012
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3274767/
https://ncbi.nlm.nih.gov/pubmed/22243422
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi201772m
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