Aphidicolin inhibits DNA synthesis by DNA polymerase alpha and isolated nuclei by a similar mechanism.

Aphidicolin is a selective inhibitor of DNA polymerase alpha. In contrast to earlier reports, the drug was found to inhibit DNA synthesis catalyzed by DNA polymerase alpha and isolated HeLa cell nuclei by a similar mechanism. For both systems aphidicolin primarily competed with dCTP incorporation. H...

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Pubblicato in:	Nucleic Acids Res
Autori principali:	Krokan, H, Wist, E, Krokan, R H
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Oxford University Press 1981
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC327469/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6795595/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/9.18.4709
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