Crystallization and preliminary X-ray diffraction analysis of orotate phosphoribosyltransferase from the human malaria parasite Plasmodium falciparum

Orotate phosphoribosyltransferase (OPRT) catalyzes the Mg(2+)-dependent condensation of orotic acid (OA) with 5-α-d-phosphorylribose 1-diphosphate (PRPP) to yield diphosphate (PP(i)) and the nucleotide orotidine 5′-monophos­phate. OPRT from Plasmodium falciparum produced in Escherichia coli was crys...

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Hauptverfasser: Takashima, Yasuhide, Mizohata, Eiichi, Tokuoka, Keiji, Krungkrai, Sudaratana R., Kusakari, Yukiko, Konishi, Saki, Satoh, Atsuko, Matsumura, Hiroyoshi, Krungkrai, Jerapan, Horii, Toshihiro, Inoue, Tsuyoshi
Format: Artigo
Sprache:Inglês
Veröffentlicht: International Union of Crystallography 2012
Schlagworte:
Crystallization Communications
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3274414/
https://ncbi.nlm.nih.gov/pubmed/22298010
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S1744309111043247
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