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Structure of human tankyrase 1 in complex with small-molecule inhibitors PJ34 and XAV939
The crystal structures of tankyrase 1 (TNKS1) in complex with two small-molecule inhibitors, PJ34 and XAV939, both at 2.0 Å resolution, are reported. The structure of TNKS1 in complex with PJ34 reveals two molecules of PJ34 bound in the NAD(+) donor pocket. One molecule is in the nicotinamide portio...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
International Union of Crystallography
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3274384/ https://ncbi.nlm.nih.gov/pubmed/22297980 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S1744309111051219 |
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