Mitochondria targeting of non-peroxidizable triphenylphosphonium conjugated oleic acid protects mouse embryonic cells against apoptosis: Role of cardiolipin remodeling

Peroxidation of cardiolipin in mitochondria is essential for the execution of apoptosis. We suggested that integration of oleic acid into cardiolipin generates non-oxidizable cardiolipin species hence protects cells against apoptosis. We synthesized mitochondria-targeted triphenylphosphonium oleic a...

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Bibliografiske detaljer
Main Authors: Tyurina, Yulia Y., Tungekar, Muhammad A., Jung, Mi-Yeon, Tyurin, Vladimir A., Greenberger, Joel S., Stoyanovsky, Detcho A., Kagan, Valerian E.
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3273856/
https://ncbi.nlm.nih.gov/pubmed/22210054
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.febslet.2011.12.016
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