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Intra-tumoral injection of CpG oligonucleotides induces the differentiation and reduces the immunosuppressive activity of myeloid-derived suppressor cells
Immunostimulatory CpG oligonucleotides (ODN) activate cells that express TLR 9 and have been shown to improve the host’s response to tumor antigens. Unfortunately, the immunosuppressive microenvironment that surrounds many cancers inhibits Ag-specific cellular responses and thus interferes with CpG-...
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| Autores principales: | , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2012
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3273593/ https://ncbi.nlm.nih.gov/pubmed/22231700 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1101304 |
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