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Pleiotropic patterning response to activation of Shh signaling in the limb Apical Ectodermal Ridge

Sonic hedgehog (Shh) signaling in the limb plays a central role in coordination of limb patterning and outgrowth. Shh expression in the limb is limited to the cells of the Zone of Polarizing Activity (ZPA), located in posterior limb bud mesoderm. Shh is not expressed by limb ectoderm or AER, but rec...

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Autors principals: Wang, Chi-Kuang Leo, Tsugane, Mizuyo H., Scranton, Victoria, Kosher, Robert A., Pierro, Louis J., Upholt, William B., Dealy, Caroline N.
Format: Artigo
Idioma:Inglês
Publicat: 2011
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3273424/
https://ncbi.nlm.nih.gov/pubmed/21465622
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/dvdy.22628
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