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Preclinical studies on histone deacetylase inhibitors as therapeutic reagents for endometrial and ovarian cancers
Histone deacetylases (HDACs) remove acetyl groups from lysine residues of histones and the deacetylation allows for tighter electrostatic interactions between DNA and histones, leading to a more compact chromatin conformation with limited access for transactivators and the suppression of transcripti...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3273414/ https://ncbi.nlm.nih.gov/pubmed/22112317 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2217/fon.11.124 |
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