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Improving TCR Gene Therapy for Treatment of Haematological Malignancies

Adoptive immunotherapy using TCR gene modified T cells may allow separation of beneficial Graft versus tumour responses from harmful GvHD. Improvements to this include methods to generate high avidity or high affinity TCR, improvements in vector design and reduction in mispairing. Following adoptive...

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Detalhes bibliográficos
Main Authors: Nicholson, Emma, Ghorashian, Sara, Stauss, Hans
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3272793/
https://ncbi.nlm.nih.gov/pubmed/22319532
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2012/404081
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