ATP11c is critical for phosphatidylserine internalization and B lymphocyte differentiation

Subcompartments of the plasma membrane are believed to be critical for lymphocyte responses but few genetic tools exist to test their function. Here we describe a new X-linked B cell deficiency syndrome in mice caused by mutations in Atp11c, a member of the P4 ATPase family thought to serve as flipp...

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Main Authors: Yabas, Mehmet, Teh, Charis E., Frankenreiter, Sandra, Lal, Dennis, Roots, Carla M., Whittle, Belinda, Andrews, Daniel T., Zhang, Yafei, Teoh, Narci C., Sprent, Jonathan, Tze, Lina E., Kucharska, Edyta M., Kofler, Jennifer, Farell, Geoffrey C., Bröer, Stefan, Goodnow, Christopher C., Enders, Anselm
Format: Artigo
Language:Inglês
Published: 2011
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3272780/
https://ncbi.nlm.nih.gov/pubmed/21423173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.2011
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