Head swivel on the ribosome facilitates translocation via intra-subunit tRNA hybrid sites

The elongation cycle of protein synthesis involves the delivery of aminoacyl-tRNAs to the A-site of the ribosome, followed by peptide-bond formation and translocation of the tRNAs through the ribosome to reopen the A-site(1,2). The translocation reaction is catalyzed by elongation factor G (EF-G) in...

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Hauptverfasser: Ratje, Andreas H., Loerke, Justus, Mikolajka, Aleksandra, Brünner, Matthias, Hildebrand, Peter W., Starosta, Agata L., Dönhöfer, Alexandra, Connell, Sean R., Fucini, Paola, Mielke, Thorsten, Whitford, Paul C., Onuchic, Jose’ N, Yu, Yanan, Sanbonmatsu, Karissa Y., Hartmann, Roland K., Penczek, Pawel A., Wilson, Daniel N., Spahn, Christian M.T.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3272701/
https://ncbi.nlm.nih.gov/pubmed/21124459
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature09547
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