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Structure of HDAC3 bound to corepressor and inositol tetraphosphate
Histone deacetylase enzymes (HDACs) are emerging cancer drug targets. They regulate gene expression by removing acetyl groups from lysine residues in histone tails resulting in chromatin condensation. The enzymatic activity of most class I HDACs requires recruitment to corepressor complexes. We repo...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3272448/ https://ncbi.nlm.nih.gov/pubmed/22230954 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature10728 |
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