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Structure of HDAC3 bound to corepressor and inositol tetraphosphate

Histone deacetylase enzymes (HDACs) are emerging cancer drug targets. They regulate gene expression by removing acetyl groups from lysine residues in histone tails resulting in chromatin condensation. The enzymatic activity of most class I HDACs requires recruitment to corepressor complexes. We repo...

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Detalles Bibliográficos
Autores principales: Watson, Peter J., Fairall, Louise, Santos, Guilherme M., Schwabe, John W.R.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2012
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3272448/
https://ncbi.nlm.nih.gov/pubmed/22230954
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature10728
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