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Prohibitin silencing reverses stabilization of mitochondrial integrity and chemoresistance in ovarian cancer cells by increasing their sensitivity to apoptosis

Current approaches to the treatment of ovarian cancer are limited because of the development of resistance to chemotherapy. Prohibitin (Phb1) is a possible candidate protein that contributes to development of drug resistance, which could be targeted in neoplastic cells. Phb1 is a highly conserved pr...

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Detalhes bibliográficos
Main Authors: Gregory-Bass, Rosalind C., Olatinwo, Moshood, Xu, Wei, Matthews, Roland, Stiles, Jonathan K., Thomas, Kelwyn, Liu, Dong, Tsang, Benjamin, Thompson, Winston E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3272361/
https://ncbi.nlm.nih.gov/pubmed/18183577
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ijc.23351
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