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Abacavir increases platelet reactivity via competitive inhibition of soluble guanylyl cyclase
OBJECTIVE: To provide a molecular mechanism that explains the association of the antiretroviral guanosine analogue, abacavir, with an increased risk of myocardial infarction. DESIGN: Drug effects were studied with biochemical and cellular assays. METHODS: Human platelets were incubated with nucleosi...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2011
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3272328/ https://ncbi.nlm.nih.gov/pubmed/21941165 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/QAD.0b013e32834d3cc3 |
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