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Abacavir increases platelet reactivity via competitive inhibition of soluble guanylyl cyclase

OBJECTIVE: To provide a molecular mechanism that explains the association of the antiretroviral guanosine analogue, abacavir, with an increased risk of myocardial infarction. DESIGN: Drug effects were studied with biochemical and cellular assays. METHODS: Human platelets were incubated with nucleosi...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Baum, Paul D., Sullam, Paul M., Stoddart, Cheryl A., McCune, Joseph M.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: 2011
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC3272328/
https://ncbi.nlm.nih.gov/pubmed/21941165
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/QAD.0b013e32834d3cc3
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