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Characterization of a R plasmid-associated, trimethoprim-resistant dihydrofolate reductase and determination of the nucleotide sequence of the reductase gene.

The trimethoprim-resistant dihydrofolate reductase associated with the R plasmid R388 was isolated from strains that over-produce the enzyme. It was purified to apparent homogeneity by affinity chromatography and two consecutive gel filtration steps under native and denaturing conditions. The purifi...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:Nucleic Acids Res
Principais autores: Zolg, J W, Hänggi, U J
פורמט: Artigo
שפה:Inglês
יצא לאור: Oxford University Press 1981
גישה מקוונת:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC327231/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6261228/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/9.3.697
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