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Circadian clock protein BMAL1 regulates cellular senescence in vivo

Deficiency of the circadian clock transcriptional factor BMAL1 results in the development of premature aging in mice. In agreement with the accelerated aging phenotype, we observed an increase in the number of senescent cells in different tissues (lungs, liver and spleen) of Bmal1(-/-) mice, which s...

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Main Authors: Khapre, Rohini V, Kondratova, Anna A, Susova, Olga, Kondratov, Roman V
Format: Artigo
Jezik:Inglês
Izdano: Landes Bioscience 2011
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3272294/
https://ncbi.nlm.nih.gov/pubmed/22101268
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.10.23.18381
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