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Circadian clock protein BMAL1 regulates cellular senescence in vivo
Deficiency of the circadian clock transcriptional factor BMAL1 results in the development of premature aging in mice. In agreement with the accelerated aging phenotype, we observed an increase in the number of senescent cells in different tissues (lungs, liver and spleen) of Bmal1(-/-) mice, which s...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Landes Bioscience
2011
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3272294/ https://ncbi.nlm.nih.gov/pubmed/22101268 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.10.23.18381 |
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