Mitochondrial oxidative stress in cancer-associated fibroblasts drives lactate production, promoting breast cancer tumor growth: Understanding the aging and cancer connection

Increasing chronological age is the most significant risk factor for cancer. Recently, we proposed a new paradigm for understanding the role of the aging and the tumor microenvironment in cancer onset. In this model, cancer cells induce oxidative stress in adjacent stromal fibroblasts. This, in turn...

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Main Authors: Balliet, Renee M, Capparelli, Claudia, Guido, Carmela, Pestell, Timothy G, Martinez-Outschoorn, Ubaldo E, Lin, Zhao, Whitaker-Menezes, Diana, Chiavarina, Barbara, Pestell, Richard G, Howell, Anthony, Sotgia, Federica, Lisanti, Michael P
Formáid: Artigo
Teanga:Inglês
Foilsithe: Landes Bioscience 2011
Ábhair:
Report
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3272288/
https://ncbi.nlm.nih.gov/pubmed/22129993
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.10.23.18254
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