Hydroxyl Radical Modification of Collagen Type II Increases Its Arthritogenicity and Immunogenicity

BACKGROUND: The oxidation of proteins by endogenously generated free radicals causes structural modifications in the molecules that lead to generation of neo-antigenic epitopes that have implications in various autoimmune disorders, including rheumatoid arthritis (RA). Collagen induced arthritis (CI...

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Bibliographic Details
Main Authors:	Shahab, Uzma, Ahmad, Saheem, Moinuddin, Dixit, Kiran, Habib, Safia, Alam, Khursheed, Ali, Asif
Format:	Artigo
Language:	Inglês
Published:	Public Library of Science 2012
Subjects:	Research Article
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC3272010/ https://ncbi.nlm.nih.gov/pubmed/22319617 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0031199
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Hydroxyl Radical Modification of Collagen Type II Increases Its Arthritogenicity and Immunogenicity

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