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Hydroxyl Radical Modification of Collagen Type II Increases Its Arthritogenicity and Immunogenicity
BACKGROUND: The oxidation of proteins by endogenously generated free radicals causes structural modifications in the molecules that lead to generation of neo-antigenic epitopes that have implications in various autoimmune disorders, including rheumatoid arthritis (RA). Collagen induced arthritis (CI...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3272010/ https://ncbi.nlm.nih.gov/pubmed/22319617 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0031199 |
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