Defective lysosomal targeting of activated fibroblast growth factor receptor 3 in achondroplasia

Mutations of fibroblast growth factor receptor 3 (FGFR3) are responsible for achondroplasia (ACH) and related dwarfing conditions in humans. The pathogenesis involves constitutive activation of FGFR3, which inhibits proliferation and differentiation of growth plate chondrocytes. Here we report that...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Cho, Jay Y., Guo, Changsheng, Torello, Monica, Lunstrum, Gregory P., Iwata, Tomoko, Deng, Chuxia, Horton, William A.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 2003
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC327195/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14699054/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.2237184100
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