Defective lysosomal targeting of activated fibroblast growth factor receptor 3 in achondroplasia

Mutations of fibroblast growth factor receptor 3 (FGFR3) are responsible for achondroplasia (ACH) and related dwarfing conditions in humans. The pathogenesis involves constitutive activation of FGFR3, which inhibits proliferation and differentiation of growth plate chondrocytes. Here we report that...

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Dades bibliogràfiques

Publicat a:	Proc Natl Acad Sci U S A
Autors principals:	Cho, Jay Y., Guo, Changsheng, Torello, Monica, Lunstrum, Gregory P., Iwata, Tomoko, Deng, Chuxia, Horton, William A.
Format:	Artigo
Idioma:	Inglês
Publicat:	National Academy of Sciences 2003
Matèries:	Biological Sciences
Accés en línia:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC327195/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14699054/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.2237184100
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