Defective lysosomal targeting of activated fibroblast growth factor receptor 3 in achondroplasia
Mutations of fibroblast growth factor receptor 3 (FGFR3) are responsible for achondroplasia (ACH) and related dwarfing conditions in humans. The pathogenesis involves constitutive activation of FGFR3, which inhibits proliferation and differentiation of growth plate chondrocytes. Here we report that...
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| Vydáno v: | Proc Natl Acad Sci U S A |
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| Hlavní autoři: | , , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
National Academy of Sciences
2003
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC327195/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14699054/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.2237184100 |
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