Triazole-containing Isothiazolidine 1,1-dioxide Library Synthesis: One-Pot, Multi-Component Protocols for Small Molecular Probe Discovery

The construction of two libraries of triazole-containing isothiazolidine 1,1-dioxides is reported utilizing either a one-pot click/aza-Michael or click/OACC esterification protocol. One core dihydroisothiazole 1,1-dioxide scaffold was prepared rapidly on multi-gram scale via RCM and was subjected to...

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Main Authors: Rolfe, Alan, Painter, Thomas O., Asad, Naeem, Hur, Moon Young, Jeon, Kyu Ok, Brzozowski, Marek, Klimberg, Sarra V., Porubsky, Patrick, Neuenswander, Benjamin, Lushington, Gerald H., Santini, Conrad, Hanson, Paul R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3271941/
https://ncbi.nlm.nih.gov/pubmed/21866904
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/co200093c
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