Bivalent recognition of nucleosomes by the tandem PHD fingers of the CHD4 ATPase is required for CHD4-mediated repression

CHD4 is a catalytic subunit of the NuRD (nucleosome remodeling and deacetylase) complex essential in transcriptional regulation, chromatin assembly and DNA damage repair. CHD4 contains tandem plant homeodomain (PHD) fingers connected by a short linker, the biological function of which remains unclea...

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Autors principals: Musselman, Catherine A., Ramírez, Julita, Sims, Jennifer K., Mansfield, Robyn E., Oliver, Samuel S., Denu, John M., Mackay, Joel P., Wade, Paul A., Hagman, James, Kutateladze, Tatiana G.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2012
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3271909/
https://ncbi.nlm.nih.gov/pubmed/22215588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1113655109
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