Structural and mechanistic insight into N-glycan processing by endo-α-mannosidase

N-linked glycans play key roles in protein folding, stability, and function. Biosynthetic modification of N-linked glycans, within the endoplasmic reticulum, features sequential trimming and readornment steps. One unusual enzyme, endo-α-mannosidase, cleaves mannoside linkages internally within an N-...

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Main Authors: Thompson, Andrew J., Williams, Rohan J., Hakki, Zalihe, Alonzi, Dominic S., Wennekes, Tom, Gloster, Tracey M., Songsrirote, Kriangsak, Thomas-Oates, Jane E., Wrodnigg, Tanja M., Spreitz, Josef, Stütz, Arnold E., Butters, Terry D., Williams, Spencer J., Davies, Gideon J.
Formáid: Artigo
Teanga:Inglês
Foilsithe: National Academy of Sciences 2012
Ábhair:
Biological Sciences
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3271872/
https://ncbi.nlm.nih.gov/pubmed/22219371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1111482109
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