Direct reprogramming of human fibroblasts into dopaminergic neuron-like cells

Transplantation of exogenous dopaminergic neuron (DA neurons) is a promising approach for treating Parkinson's disease (PD). However, a major stumbling block has been the lack of a reliable source of donor DA neurons. Here we show that a combination of five transcriptional factors Mash1, Ngn2,...

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Autors principals: Liu, Xinjian, Li, Fang, Stubblefield, Elizabeth A, Blanchard, Barbara, Richards, Toni L, Larson, Gaynor A, He, Yujun, Huang, Qian, Tan, Aik-Choon, Zhang, Dabing, Benke, Timothy A, Sladek, John R, Zahniser, Nancy R, Li, Chuan-Yuan
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2012
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3271588/
https://ncbi.nlm.nih.gov/pubmed/22105488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cr.2011.181
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