Complement 1s is the Serine Protease that Cleaves IGFBP-5 in Human Osteoarthritic Joint Fluid

Insulin-like growth factor-I (IGF-I) and IGF binding proteins (IGFBPs) are trophic factors for cartilage and have been shown to be chondroprotective in animal models of osteoarthritis. IGFBP-5 is degraded in joint fluid and inhibition of IGFBP-5 degradation has been shown to enhance the trophic effe...

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Detalhes bibliográficos
Main Authors: Busby, Walker H., Yocum, Sue A., Rowland, Michael, Kellner, Debra, Lazerwith, Scott, Sverdrup, Francis, Yates, Matthew, Radabaugh, Melissa, Clemmons, David R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3271436/
https://ncbi.nlm.nih.gov/pubmed/18930415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.joca.2008.08.004
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