Identifying gene regulatory elements by genome-wide recovery of DNase hypersensitive sites

Analysis of the human genome sequence has identified ≈25,000–30,000 protein-coding genes, but little is known about how most of these are regulated. Mapping DNase I hypersensitive (HS) sites has traditionally represented the gold-standard experimental method for identifying regulatory elements, but...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Crawford, Gregory E., Holt, Ingeborg E., Mullikin, James C., Tai, Denise, Green, Eric D., Wolfsberg, Tyra G., Collins, Francis S.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 2004
Soggetti:	Biological Sciences
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC327130/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14732688/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0307540100
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