Identifying gene regulatory elements by genome-wide recovery of DNase hypersensitive sites

Analysis of the human genome sequence has identified ≈25,000–30,000 protein-coding genes, but little is known about how most of these are regulated. Mapping DNase I hypersensitive (HS) sites has traditionally represented the gold-standard experimental method for identifying regulatory elements, but...

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Bibliographische Detailangaben
Hauptverfasser: Crawford, Gregory E., Holt, Ingeborg E., Mullikin, James C., Tai, Denise, Green, Eric D., Wolfsberg, Tyra G., Collins, Francis S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2004
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC327130/
https://ncbi.nlm.nih.gov/pubmed/14732688
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0307540100
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