Functional analysis of arylamine N-acetyltransferase 1 (NAT1) NAT1*10 haplotypes in a complete NATb mRNA construct

N-acetyltransferase 1 (NAT1) catalyzes N-acetylation of arylamines as well as the O-acetylation of N-hydroxylated arylamines. O-acetylation leads to the formation of electrophilic intermediates that result in DNA adducts and mutations. NAT1*10 is the most common variant haplotype and is associated w...

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Bibliographic Details
Main Authors: Millner, Lori M., Doll, Mark A., Stepp, Marcus W., States, J.Christopher, Hein, David W.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2012
Subjects:
Cancer Biomarkers and Molecular Epidemiology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3271262/
https://ncbi.nlm.nih.gov/pubmed/22114069
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgr273
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