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Phenotype of the Most Common “Slow Acetylator” Arylamine N-Acetyltransferase 1 Genetic Variant (NAT1*14B) Is Substrate-Dependent

Human arylamine N-acetyltransferase 1 (NAT1) is a phase II cytosolic enzyme responsible for the activation or deactivation of many arylamine compounds including pharmaceuticals and environmental carcinogens. NAT1 is highly polymorphic and has been associated with altered risk toward many cancers. NA...

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Главные авторы: Millner, Lori M., Doll, Mark A., Cai, Jian, States, J. Christopher, Hein, David W.
Формат: Artigo
Язык:Inglês
Опубликовано: The American Society for Pharmacology and Experimental Therapeutics 2012
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3250052/
https://ncbi.nlm.nih.gov/pubmed/22010219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.111.041855
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