Phenotype of the Most Common “Slow Acetylator” Arylamine N-Acetyltransferase 1 Genetic Variant (NAT1*14B) Is Substrate-Dependent

Human arylamine N-acetyltransferase 1 (NAT1) is a phase II cytosolic enzyme responsible for the activation or deactivation of many arylamine compounds including pharmaceuticals and environmental carcinogens. NAT1 is highly polymorphic and has been associated with altered risk toward many cancers. NA...

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Bibliografiske detaljer
Main Authors: Millner, Lori M., Doll, Mark A., Cai, Jian, States, J. Christopher, Hein, David W.
Format: Artigo
Sprog:Inglês
Udgivet: The American Society for Pharmacology and Experimental Therapeutics 2012
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3250052/
https://ncbi.nlm.nih.gov/pubmed/22010219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.111.041855
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